ADAMTS-4 as a possible distinguishing indicator between osteoarthritis and haemophilic arthropathy.

ABSTRACT:

Introduction

Osteoarthritis (OA) and haemophilic arthropathy (HA) are clinically similar, but pathologically distinct conditions which result in joint pain and loss of function. Distinguishing their disease mechanisms is therefore a key step in the development of curative therapy, as opposed to current symptomatic treatments. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) 4 is a metzincin-family member proteoglycan with known local involvement in OA pathogenesis.

Aim

To investigate the potential differences and discriminatory potential of ADAMTS-4 between OA and HA patients.

Methods

We determined ADAMTS-4 plasma concentrations by ELISA in patients with HA and OA. This pilot cross-sectional study included N = 40 male participants equally divide

SUBMITTER: Kalebota N 

PROVIDER: S-EPMC9544250 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature