16S rRNA gene sequencing reveals altered composition of gut microbiota in postoperative individuals with renal stones.

ABSTRACT: Renal stones are a common urological disease with high prevalence and recurrence rates. Characterizing gut microbiome profiles of first-onset renal calculi patients, both before and after surgery, may provide valuable insights and identify potential biomarkers for the disease. In this study, we explored the associations between the gut microbiome and renal stone formation using 16S ribosomal RNA (rRNA) gene sequencing. In brief, 20 patients were recruited, and information on health and eating habits within the previous 1-3 months was collected upon admission. A total of 493 operational taxonomic units (OTUs) were detected in 40 specimens, with an average of 67,888 ± 827 reads per sample. The results of OTU-based partial least squares discriminant analysis (PLS-DA) analysis showed differenc

SUBMITTER: Deng Q 

PROVIDER: S-EPMC9544399 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature