Optimized design of an arterial network model reproduces characteristic central and peripheral haemodynamic waveform features of young adults.

ABSTRACT: The arterial network in healthy young adults is thought to be structured to optimize wave reflection in the arterial system, producing an ascending aortic pressure waveform with three key features: early systolic peak, negative systolic augmentation and diastolic hump. One-dimensional computer models have provided significant insights into arterial haemodynamics, but no previous models of the young adult have exhibited these three features. Given that this issue was likely to be related to unrepresentative or non-optimized impedance properties of the model arterial networks, we developed a new 'YoungAdult' model that incorporated the following features: (i) a new and more accurate empirical equation for approximating wave speeds, based on area and relative distance to elastic-muscular arte

SUBMITTER: Kondiboyina A 

PROVIDER: S-EPMC9544402 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature