Association between early change in neutrophil-to-lymphocyte ratio after radical cystectomy and treatment outcomes.

ABSTRACT:

Objectives

To evaluate the associations of peri-operative neutrophil-to-lymphocyte ratio (NLR) and change in NLR with survival after radical cystectomy.

Patients and methods

We retrospectively reviewed a multicentre cohort of patients with bladder cancer who underwent radical cystectomy between 2010 and 2020. Preoperative NLR, postoperative NLR, delta-NLR (postoperative minus preoperative NLR) and NLR change (postoperative divided by preoperative NLR) were calculated. Patients were stratified based on elevation of preoperative and/ or postoperative NLR above the median values. Multivariable Cox regression models were used to evaluate the associations of peri-operative NLR and NLR change with survival.

Results

The study cohort included 346 patients with a median age of

SUBMITTER: Herzberg H 

PROVIDER: S-EPMC9544470 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature