The additive effect of periodontitis with hypertension on risk of systemic disease and mortality.

ABSTRACT:

Background

Recent evidence suggests that periodontitis (PD) causes hypertension, which is a precursor to development of other systemic diseases. The aim of this study was to examine the effect of hypertension and PD on the risk of subsequent systemic disease.

Methods

This longitudinal cohort study included 244,393 UK Biobank participants who were free of systemic disease other than hypertension at baseline. Self-reported responses of painful gums or loose teeth were surrogates for PD. Hypertensives were identified by clinical diagnosis, or elevated blood pressure (≥140/90 mmHg). Systemic diseases including cancer, cardiovascular disease (CVD), and diabetes were identified from linked diagnostic codes. Multivariable Cox proportional hazard models were used to quantify the ris

SUBMITTER: Larvin H 

PROVIDER: S-EPMC9544472 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature