The genomic landscape of blood groups in Indigenous Australians in remote communities.

ABSTRACT:

Background

Red blood cell (RBC) membrane-associated blood group systems are clinically significant. Alloimmunisation is a persistent risk associated with blood transfusion owing to the antigen polymorphisms among these RBC-associated blood groups. Next-generation sequencing (NGS) offers an opportunity to characterize the blood group variant profile of a given individual. Australia comprises a large multiethnic population where most blood donors are Caucasian and blood group variants remain poorly studied among Indigenous Australians. In this study, we focused on the Tiwi Islanders, who have lived in relative isolation for thousands of years.

Methods and materials

We predicted the blood group phenotype profiles in the Tiwi (457) and 1000 Genomes Phase 3 (1KGP3-2504) cohort in

SUBMITTER: Jadhao S 

PROVIDER: S-EPMC9544628 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature