Characterisation of individual ferritin response in patients receiving chelation therapy.

ABSTRACT:

Aims

To develop a drug-disease model describing iron overload and its effect on ferritin response in patients affected by transfusion-dependent haemoglobinopathies and investigate the contribution of interindividual differences in demographic and clinical factors on chelation therapy with deferiprone or deferasirox.

Methods

Individual and mean serum ferritin data were retrieved from 13 published studies in patients affected by haemoglobinopathies receiving deferiprone or deferasirox. A nonlinear mixed effects modelling approach was used to characterise iron homeostasis and serum ferritin production taking into account annual blood consumption, baseline demographic and clinical characteristics. The effect of chelation therapy was parameterised as an increase in the iron elimi

SUBMITTER: Borella E 

PROVIDER: S-EPMC9544664 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature