Genetic variation in chicken interferon signalling pathway genes in research lines showing differential viral resistance.

ABSTRACT: Avian viruses of economic interest are a significant burden on the poultry industry, affecting production traits and resulting in mortality. Furthermore, the zoonosis of avian viruses risks pandemics developing in humans. Vaccination is the most common method of controlling viruses; however current vaccines often lack cross-protection against multiple strains of each virus. The mutagenicity of these viruses has also led to virulent strains emerging that can overcome the protection offered by vaccines. Breeding chickens with a more robust innate immune response may help in tackling current and emerging viruses. Understanding the genetic evolution of different lines will thus provide a useful tool in helping the host in the fight against pathogens. This study focuses on the interferon genes

SUBMITTER: Mountford J 

PROVIDER: S-EPMC9544680 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature