Biomarkers in asthma in the context of atopic dermatitis in young children.

ABSTRACT:

Background

Diverse pathways stemming from a history of atopic dermatitis (AD) might modulate different biomarkers associated with the development of asthma. Biomarkers associated with AD and asthma separately have been investigated, but none have characterized a combined AD+asthma phenotype. We investigated the clinical and molecular characteristics associated with an AD+asthma phenotype compared with AD, asthma and controls.

Methods

From a prospective birth cohort and the outpatient allergy clinic, we included four groups of 6-12-year-old children: (1) healthy controls (2) previous, current, or present AD without asthma, (3) previous, current, or present AD and current asthma and (4) current asthma without AD. We performed clinical examinations and interviews and measured s

SUBMITTER: Basu MN 

PROVIDER: S-EPMC9544684 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature