Increased cytokine gene expression and cognition risk associated with androgen deprivation therapy.

ABSTRACT:

Background

Androgen deprivation therapy (ADT) is a standard treatment modality for locally advanced, high-risk, and metastatic hormone-sensitive prostate cancer. Long-term ADT treatment likely develops side-effects that include changes in cognition or onset of dementia. However, the molecular understanding of this effect remains elusive. We attempt to establish a link between ADT and changes in cognitive function using patient databases and bioinformatics analyses.

Methods

Gene expression profiling was performed using RNA sequencing data from Alzheimer patient cohort and compared with the data from advanced-stage prostate cancer patients receiving neoadjuvant antiandrogen therapy. Differentially expressed genes (DEGs) were analyzed using the Ingenuity knowledge database.

SUBMITTER: Verma S 

PROVIDER: S-EPMC9544768 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature