Antiviral plant-derived natural products to combat RNA viruses: Targets throughout the viral life cycle.

ABSTRACT: There is a need for new effective antivirals, particularly in response to the development of antiviral drug resistance and emerging RNA viruses such as SARS-CoV-2. Plants are a significant source of structurally diverse bioactive compounds for drug discovery suggesting that plant-derived natural products could be developed as antiviral agents. This article reviews the antiviral activity of plant-derived natural products against RNA viruses, with a focus on compounds targeting specific stages of the viral life cycle. A range of plant extracts and compounds have been identified with antiviral activity, often against multiple virus families suggesting they may be useful as broad-spectrum antiviral agents. The antiviral mechanism of action of many of these phytochemicals is not fully understoo

SUBMITTER: Owen L 

PROVIDER: S-EPMC9544774 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature