Ciprofloxacin exposure and adverse pregnancy outcomes: A Danish nationwide cohort study.

ABSTRACT:

Objective

To examine the association between maternal exposure to ciprofloxacin and the risk of miscarriage and major malformations.

Design

A nationwide register-based cohort study.

Setting

Data were obtained from the Medical Birth Registry, the National Hospital Registry, the Danish National Prescription Registry and Statistics Denmark.

Population

Data were collected in the period between 1997 and 2016 and included all registered pregnancies that ended in an elective termination, miscarriage, stillbirth or a live birth. Exposure was defined as redeeming one or more prescriptions of ciprofloxacin.

Methods

Miscarriage was defined as a diagnosis given before 22 weeks without any medical intervention. Major malformations were classified according to EUROCAT

SUBMITTER: Noergaard M 

PROVIDER: S-EPMC9544954 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature