MRNIP interacts with sex body chromatin to support meiotic progression, spermatogenesis, and male fertility in mice.

ABSTRACT: Meiosis has a principal role in sexual reproduction to generate haploid gametes in both sexes. During meiosis, the cell nucleus hosts a dynamic environment where some genes are transcriptionally activated, and some are inactivated at the same time. This becomes possible through subnuclear compartmentalization. The sex body, sequestering X and Y chromosomes during male meiosis and creating an environment for the meiotic sex chromosome inactivation (MSCI) is one of the best known and studied subnuclear compartments. Herein, we show that MRNIP forms droplet-like accumulations that fuse together to create a distinct subnuclear compartment that partially overlaps with the sex body chromatin during diplotene. We demonstrate that Mrnip^-/- spermatocytes have impaired DNA double-strand b

SUBMITTER: Kazi S 

PROVIDER: S-EPMC9544956 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature