Adrenal androgens versus cortisol for primary aldosteronism subtype determination in adrenal venous sampling.

ABSTRACT:

Objective

We examined if measurement of adrenal androgens adds to subtype diagnostics of primary aldosteronism (PA) under cosyntropin-stimulated adrenal venous sampling (AVS).

Design

A prospective pre-specified secondary endpoint analysis of 49 patients with confirmed PA, of whom 29 underwent unilateral adrenalectomy with long-term follow-up.

Methods

Concentrations of androstenedione, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) were measured during AVS in addition to aldosterone and cortisol. Subjects with lateralisation index (LI) of ≥4 were treated with unilateral adrenalectomy, and the immunohistochemical subtype was determined with CYP11B2 and CYP11B1 stains. The performance of adrenal androgens was evaluated by receiver operating cha

SUBMITTER: Viukari M 

PROVIDER: S-EPMC9544970 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature