Risk of dementia in patients with inflammatory bowel disease: a Danish population-based study.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) may be associated with increased dementia risk, but the literature is conflicting.

Aim

To investigate dementia risk in patients with IBD.

Methods

We conducted a nationwide population-based cohort study in Denmark (1977-2018) including all patients with incident IBD matched with up to 10 general population comparators without IBD by sex, year of birth and region of residence. We calculated cumulative incidence proportions (CIPs) of dementia treating death as a competing risk, and adjusted hazard ratios (HRs) comparing IBD patients with matched comparisons. In a nested case-control analysis, we investigated the impact of IBD severity, steroid use, colorectal and small bowel surgery, and healthcare system contacts on dementia r

SUBMITTER: Ronnow Sand J 

PROVIDER: S-EPMC9545113 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature