Multi-echo quantitative susceptibility mapping: how to combine echoes for accuracy and precision at 3 Tesla.

ABSTRACT:

Purpose

To compare different multi-echo combination methods for MRI QSM. Given the current lack of consensus, we aimed to elucidate how to optimally combine multi-echo gradient-recalled echo signal phase information, either before or after applying Laplacian-base methods (LBMs) for phase unwrapping or background field removal.

Methods

Multi-echo gradient-recalled echo data were simulated in a numerical head phantom, and multi-echo gradient-recalled echo images were acquired at 3 Tesla in 10 healthy volunteers. To enable image-based estimation of gradient-recalled echo signal noise, 5 volunteers were scanned twice in the same session without repositioning. Five QSM processing pipelines were designed: 1 applied nonlinear phase fitting over TEs before LBMs; 2 applied LBMs to th

SUBMITTER: Biondetti E 

PROVIDER: S-EPMC9545116 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature