Association between sustained virological response and clinical outcomes in patients with hepatitis C infection and hepatocellular carcinoma.

ABSTRACT:

Background

Sustained viral response (SVR) improves survival for patients with hepatitis C (HCV) and hepatocellular carcinoma (HCC) after curative treatment; however, the benefit of SVR in those with active HCC with a significant competing risk of mortality is unknown. This study aimed to evaluate the association between SVR and outcomes in patients with active HCC.

Methods

The authors performed a multicenter, retrospective cohort study including consecutive adults with HCV cirrhosis and treatment-naive HCC diagnosed between 2014 and 2018. Patients were stratified into two groups: active viremia (n = 431) and SVR before HCC diagnosis (n = 135). All patients underwent nonsurgical therapy as their initial treatment and were followed until liver transplantation, last follow-up,

SUBMITTER: Parikh ND 

PROVIDER: S-EPMC9545187 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature