A metabolite panel that differentiates Alzheimer's disease from other dementia types.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is associated with altered metabolites. This study aimed to determine the validity of using circulating metabolites to differentiate AD from other dementias.

Methods

Blood metabolites were measured in three data sets. Data set 1 (controls, 27; AD, 28) was used for analyzing differential metabolites. Data set 2 (controls, 93; AD, 92) was used to establish a diagnostic AD model with use of a metabolite panel. The model was applied to Data set 3 (controls, 76; AD, 76; other dementias, 205) to verify its capacity for differentiating AD from other dementias.

Results

Data set 1 revealed 7 upregulated and 77 downregulated metabolites. In Data set 2, a panel of 11 metabolites was included in a model that could distinguish AD from controls

SUBMITTER: Jia L 

PROVIDER: S-EPMC9545206 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature