Onset of efficacy and adverse events during Cenobamate titration period.

ABSTRACT:

Objectives

Cenobamate is an antiseizure medication (ASM) approved in Europe as adjunctive therapy for adults with inadequately controlled focal seizures. This post hoc analysis reports onset of efficacy and characterizes time to onset, duration, and severity of the most common treatment-emergent adverse events (TEAEs) during cenobamate titration.

Materials & methods

Adult patients with uncontrolled focal seizures taking 1 to 3 concomitant ASMs were randomized to receive adjunctive cenobamate or placebo (double-blind studies C013 and C017) or cenobamate (open-label study C021). Outcome assessments included efficacy (median percentage change in seizure frequency and onset [studies C013 and C017]) and safety (onset, duration, and severity of TEAEs [all studies]).

Results

SUBMITTER: Steinhoff BJ 

PROVIDER: S-EPMC9545218 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature