Two-year follow-up of infant and maternal outcomes after planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): A randomised controlled trial.

ABSTRACT:

Objective

We evaluated the best time to initiate delivery in late preterm pre-eclampsia in order to optimise long-term infant and maternal outcomes.

Design

Parallel-group, non-masked, randomised controlled trial.

Setting

Forty-six maternity units in the UK.

Population

Women with pre-eclampsia between 34⁺⁰ and 36⁺⁶  weeks of gestation, without severe disease, were randomised to planned delivery or expectant management.

Main outcome measures

Infant neurodevelopmental outcome at 2 years of age, using the Parent Report of Children's Abilities - Revised (PARCA-R) composite score.

Results

Between 29 September 2014 and 10 December 2018, 901 women were enrolled in the trial, with 450 women allocated to planned delivery and 451 women

SUBMITTER: Beardmore-Gray A 

PROVIDER: S-EPMC9545311 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature