Outcomes reported in trials of treatments for severe malaria: The need for a core outcome set.

ABSTRACT:

Objectives

Malaria is one of the most important parasitic infectious diseases worldwide. Despite the scale-up of effective antimalarials, mortality rates from severe malaria (SM) remain significantly high; thus, numerous trials are investigating both antimalarials and adjunctive therapy. This review aimed to summarise all the outcome measures used in trials in the last 10 years to see the need for a core outcome set.

Methods

A systematic review was undertaken to summarise outcomes of individually randomised trials assessing treatments for SM in adults and children. We searched key databases and trial registries between 1 January 2010 and 30 July 2020. Non-randomised trials were excluded to allow comparison of similar trials. Trial characteristics including phase, region, pop

SUBMITTER: Lampro L 

PROVIDER: S-EPMC9545330 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature