Temporal variation of high-level pyrethroid resistance in the major malaria vector Anopheles gambiae s.l. in Yaounde, Cameroon, is mediated by target-site and metabolic resistance.

ABSTRACT: Constant assessment of insecticide resistance levels is mandatory to implement adequate malaria control tools, but little information is available on the annual dynamics of resistance. We, therefore, monitored variations in resistance in Anopheles gambiae s.l. over four seasons during 2 years in two localities of Yaoundé: urban Etoa-Meki and peri-urban Nkolondom. Mosquitoes were collected seasonally at larval stage and reared to adults for insecticide susceptibility tests and molecular analysis of resistance mechanisms. Anopheles coluzzii was found in Etoa-Meki and An. gambiae in Nkolondom. Low mortalities to pyrethroids were observed (permethrin <10%, deltamethrin <21%), and resistance extended to 5× and 10× diagnostic doses, revealing a marked increase compared to previous studies. A sea

SUBMITTER: Tene-Fossog B 

PROVIDER: S-EPMC9545389 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature