Modeling the Effect of Hyperoxia on the Spin-Lattice Relaxation Rate R1 of Tissues.

ABSTRACT:

Purpose

Inducing hyperoxia in tissues is common practice in several areas of research, including oxygen-enhanced MRI (OE-MRI), which attempts to use the resulting signal changes to detect regions of tumor hypoxia or pulmonary disease. The linear relationship between PO₂ and R1 has been reproduced in phantom solutions and body fluids such as vitreous fluid; however, in tissue and blood experiments, factors such as changes in deoxyhemoglobin levels can also affect the ΔR1.

Theory and methods

This manuscript proposes a three-compartment model for estimating the hyperoxia-induced changes in R1 of tissues depending on B0, SO₂ , blood volume, hematocrit, oxygen extraction fraction, and changes in blood and tissue PO₂ . The model contains two blood

SUBMITTER: Bluemke E 

PROVIDER: S-EPMC9545427 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature