Characterization of eosinophilic esophagitis variants by clinical, histological, and molecular analyses: A cross-sectional multi-center study.

ABSTRACT:

Objective

Physicians are increasingly confronted with patients presenting with symptoms of esophageal dysfunction resembling eosinophilic esophagitis (EoE), but absence of significant esophageal eosinophilia. The purpose of this study was to characterize and classify this group of EoE variants.

Design

Patients from six EoE-centers with symptoms of esophageal dysfunction, but peak eosinophil counts of <60/mm² (<15/hpf) in esophageal biopsies and absence of gastro-esophageal reflux disease (GERD) were included. Clinical, endoscopic, (immuno)-histological, and molecular features were determined and compared with EoE, GERD, and healthy controls.

Results

We included 69 patients with EoE variants. Endoscopic abnormalities were found in 53.6%. We identified three

SUBMITTER: Greuter T 

PROVIDER: S-EPMC9545458 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature