Cancer-associated fibroblasts in nonsmall cell lung cancer: From molecular mechanisms to clinical implications.

ABSTRACT: Lung cancer is the common and leading cause of cancer death worldwide. The tumor microenvironment has been recognized to be instrumental in tumorigenesis. To have a deep understanding of the molecular mechanism of nonsmall cell lung carcinoma (NSCLC), cancer-associated fibroblasts (CAFs) have gained increasing research interests. CAFs belong to the crucial and dominant cell population in the tumor microenvironment to support the cancer cells. The interplay and partnership between cancer cells and CAFs contribute to each stage of tumorigenesis. CAFs exhibit prominent heterogeneity and secrete different kinds of cytokines and chemokines, growth factors and extracellular matrix proteins involved in cancer cell proliferation, invasion, metastasis and chemoresistance. Many studies focused on th

SUBMITTER: Wong KY 

PROVIDER: S-EPMC9545594 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature