Cell-type specific transcriptomic signatures of neocortical circuit organization and their relevance to autism.

ABSTRACT: A prevailing challenge in neuroscience is understanding how diverse neuronal cell types select their synaptic partners to form circuits. In the neocortex, major classes of excitatory projection neurons and inhibitory interneurons are conserved across functionally distinct regions. There is evidence these classes form canonical circuit motifs that depend primarily on their identity; however, regional cues likely also influence their choice of synaptic partners. We mined the Allen Institute's single-cell RNA-sequencing database of mouse cortical neurons to study the expression of genes necessary for synaptic connectivity and physiology in two regions: the anterior lateral motor cortex (ALM) and the primary visual cortex (VISp). We used the Allen's metadata to parse cells by clusters represen

SUBMITTER: Moussa AJ 

PROVIDER: S-EPMC9545608 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature