Dysbiosis of skin microbiota with increased fungal diversity is associated with severity of disease in atopic dermatitis.

ABSTRACT:

Background

Atopic dermatitis (AD) is a multifactorial inflammatory skin disease and an altered skin microbiota with an increase of Staphylococcus aureus has been reported. However, the role of fungi remains poorly investigated.

Objectives

We aimed to improve the understanding of the fungal skin microbiota, the mycobiota, in AD in relation to the bacterial colonization.

Methods

Skin swabs of 16 AD patients and 16 healthy controls (HC) from four different skin sites, that is antecubital crease, dorsal neck, glabella and vertex from multiple time points were analysed by DNA sequencing of the internal transcribed spacer region 1 (ITS1) and 16S rRNA gene for fungi and bacteria, respectively.

Results

Malassezia spp. were the predominant fungi in all subjects but with

SUBMITTER: Schmid B 

PROVIDER: S-EPMC9545669 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature