Viral infection-related gene upregulation in monocytes in children with signs of β-cell autoimmunity.

ABSTRACT:

Objective

The pathogenesis of type 1 diabetes (T1D) is associated with genetic predisposition and immunological changes during presymptomatic disease. Differences in immune cell subset numbers and phenotypes between T1D patients and healthy controls have been described; however, the role and function of these changes in the pathogenesis is still unclear. Here we aimed to analyze the transcriptomic landscapes of peripheral blood mononuclear cells (PBMCs) during presymptomatic disease.

Methods

Transcriptomic differences in PBMCs were compared between cases positive for islet autoantibodies and autoantibody negative controls (9 case-control pairs) and further in monocytes and lymphocytes separately in autoantibody positive subjects and control subjects (25 case-control pairs).<

SUBMITTER: Valta M 

PROVIDER: S-EPMC9545759 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature