MiR-378a regulates keratinocyte responsiveness to interleukin-17A in psoriasis.

ABSTRACT:

Background

Psoriasis is an immune-mediated inflammatory skin disease, in which an interplay between infiltrating immune cells and keratinocytes sustains chronic skin inflammation. Interleukin (IL)-17A is a key inflammatory cytokine in psoriasis and its main cellular targets are keratinocytes.

Objectives

To explore the role of miR-378a in psoriasis.

Methods

Keratinocytes obtained from psoriatic skin and healthy epidermis were separated by magnetic sorting, and the expression of miR-378a was analysed by quantitative polymerase chain reaction. The regulation and function of miR-378a was studied using primary human keratinocytes. The expression of miR-378a was modulated by synthetic mimics, and nuclear factor kappa B (NF-κB) activity and transcriptomic changes were studie

SUBMITTER: Xia P 

PROVIDER: S-EPMC9545829 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature