Macromolecular background signal and non-Gaussian metabolite diffusion determined in human brain using ultra-high diffusion weighting.

ABSTRACT:

Purpose

Definition of a macromolecular MR spectrum based on diffusion properties rather than relaxation time differences and characterization of non-Gaussian diffusion of brain metabolites with strongly diffusion-weighted MR spectroscopy.

Methods

Short echo time MRS with strong diffusion-weighting with b-values up to 25 ms/μm² at two diffusion times was implemented on a Connectom system and applied in combination with simultaneous spectral and diffusion decay modeling. Motion-compensation was performed with a combined method based on the simultaneously acquired water and a macromolecular signal.

Results

The motion compensation scheme prevented spurious signal decay reflected in very small apparent diffusion constants for macromolecular signal. Macromolecula

SUBMITTER: Simsek K 

PROVIDER: S-EPMC9545875 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature