Association of THBS1 genetic variants and mRNA expression with the risks of ischemic stroke and long-term death after stroke.

ABSTRACT:

Background

Thrombospondin-1 (THBS1) derived from platelets and acted as a critical mediator of hemostasis promoting platelet activation in thrombus formation. The biological connection of genetic variants and mRNA expression of THBS1 with ischemic stroke (IS) warrants further validation with population-based evidence.

Objective

To evaluate the association of single nucleotide polymorphisms (SNPs) and mRNA expression of THBS1 with the risks of IS and long-term death after stroke.

Methods

A case-control study consisted of 4,584 IS patients recruited from five hospitals in Jiangsu, China, and 4,663 age-gender-matched controls free of IS. A cohort study enrolled 4,098 participants free of stroke and lasted from 2009 to 2022. Early collected 3158 IS patients

SUBMITTER: Chen C 

PROVIDER: S-EPMC9545898 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature