Free vitamin D₃ index and vitamin D-binding protein in multiple sclerosis: A presymptomatic case-control study.

ABSTRACT:

Background and purpose

High levels of 25-hydroxyvitamin D₃ (25[OH]D₃ ) are associated with a lower risk for multiple sclerosis (MS). The bioavailability of 25(OH)D₃ is regulated by its main plasma carrier, vitamin D-binding protein (DBP). Free 25(OH)D₃ can be estimated by also measuring DBP concentration. In addition, DBP has immunomodulatory functions that may independently affect MS pathogenesis. No previous studies have assessed free 25(OH)D₃ or DBP in presymptomatically collected samples. This study was undertaken to assess free 25(OH)D₃ and DBP as risk factors for MS.

Methods

A nested case-control study was performed with presymptomatic serum samples identified through cross-linkage of MS registries and S

SUBMITTER: Grut V 

PROVIDER: S-EPMC9545920 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature