The zebrafish cohesin protein Sgo1 is required for cardiac function and eye development.

ABSTRACT:

Background

Cohesinopathies is a term that refers to/covers rare genetic diseases caused by mutations in the cohesin complex proteins. The cohesin complex is a multiprotein complex that facilitates different aspects of cell division, gene transcription, DNA damage repair, and chromosome architecture. Shugoshin proteins prevent the cohesin complex from premature dissociation from chromatids during cell division. Patients with a homozygous missense mutation in SGO1, which encodes for Shugoshin1, have problems with normal pacing of the heart and gut.

Results

To study the role of shugoshin during embryo development, we mutated the zebrafish sgo1 gene. Homozygous sgo1 mutant embryos display various phenotypes related to different organs, including a reduced heart rate accompanied

SUBMITTER: Kamel SM 

PROVIDER: S-EPMC9545960 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature