Assessing evolutionary and developmental transcriptome dynamics in homologous cell types.

ABSTRACT:

Background

During development, complex organ patterns emerge through the precise temporal and spatial specification of different cell types. On an evolutionary timescale, these patterns can change, resulting in morphological diversification. It is generally believed that homologous anatomical structures are built-largely-by homologous cell types. However, whether a common evolutionary origin of such cell types is always reflected in the conservation of their intrinsic transcriptional specification programs is less clear.

Results

Here, we developed a user-friendly bioinformatics workflow to detect gene co-expression modules and test for their conservation across developmental stages and species boundaries. Using a paradigm of morphological diversification, the tetrapod limb,

SUBMITTER: Feregrino C 

PROVIDER: S-EPMC9545966 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature