Epidemiology and long-term neurological sequelae of childhood herpes simplex CNS infection.

ABSTRACT:

Aim

Herpes simplex CNS infection is a rare but important cause of neurological disability. Long term outcomes after HSV CNS infection in Australia have not yet been fully described. We sought to provide a comprehensive review of HSV CNS infection in children using a retrospective 13-year evaluation of statewide laboratory and clinical records and a parent survey conducted at least one year after the initial infection.

Methods

All positive PCR HSV 1 and 2 results from cerebrospinal fluid (CSF) or brain tissue were obtained from Queensland pathology providers for children aged 0-16 years between 1 January 2005 and 31 December 2017. Clinical data were obtained from patient records and longer-term outcomes via parent survey at least 1 year after initial infection.

Results

SUBMITTER: Berkhout A 

PROVIDER: S-EPMC9546081 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature