Fat-associated lymphoid clusters as expandable niches for ectopic liver development.

ABSTRACT:

Background and aims

Hepatocyte transplantation holds great promise as an alternative approach to whole-organ transplantation. Intraportal and intrasplenic cell infusions are primary hepatocyte transplantation delivery routes for this procedure. However, patients with severe liver diseases often have disrupted liver and spleen architectures, which introduce risks in the engraftment process. We previously demonstrated i.p. injection of hepatocytes as an alternative route of delivery that could benefit this subpopulation of patients, particularly if less invasive and low-risk procedures are required; and we have established that lymph nodes may serve as extrahepatic sites for hepatocyte engraftment. However, whether other niches in the abdominal cavity support the survival and prolife

SUBMITTER: Han B 

PROVIDER: S-EPMC9546108 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature