House dust mite sensitization and exposure affects bronchial epithelial anti-microbial response to viral stimuli in patients with asthma.

ABSTRACT:

Introduction

Allergen exposure worsens viral-triggered asthma exacerbations and could predispose the host to secondary bacterial infections. We have previously demonstrated that exposure to house dust mite (HDM) reduced TLR-3-induced IFN-β in human bronchial epithelial cells (HBECs) from healthy donors. We hypothesize that HDM sensitization in different ways may be involved in both viral and bacterial resistance of HBECs in asthma. In this study, the role of HDM sensitization and effects of HDM exposure on viral stimulus-challenged HBECs from asthmatic donors have been explored with regard to expression and release of molecules involved in anti-viral and anti-bacterial responses, respectively.

Methods

HBECs from HDM-sensitized (HDM+) and unsensitized (HDM-) patients with ast

SUBMITTER: Cerps S 

PROVIDER: S-EPMC9546181 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature