Secretory leukocyte protease inhibitor regulates nerve reflex-mediated skin barrier function in psoriasis.

ABSTRACT:

Background

Secretory leukocyte protease inhibitor (SLPI), a ~12 kDa protein is an important regulator of innate and adaptive immunity and a component of tissue regenerative programmes. SLPI expression is markedly elevated in chronically inflamed skin, including that of individuals suffering from psoriasis. However, the role of SLPI in these diseases remains elusive.

Objectives

The poor understanding of the early stages of the development of psoriasis is a major obstacle to successful intervention in the skin pathology. We hypothesized that SLPI and peripheral nerves that might be activated early in the progression of the disease likely form a functional relationship to maintain skin barrier homeostasis and respond to a variety of threats.

Methods

We used skin biopsies

SUBMITTER: Kwiecinska P 

PROVIDER: S-EPMC9546283 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature