Medication control of flunixin in racing horses: Possible detection times using Monte Carlo simulations.

ABSTRACT:

Background

For medication control in several jurisdictions, withdrawal time is the period of refrain from racing after drug administration. It is set by adding a safety period to an experimental detection time. However, there are no reports of statistical analyses of detection time for the determination of withdrawal time in flunixin meglumine-treated horses.

Objective

To analyse the population pharmacokinetics of flunixin in horses through the generation of a dataset for detection time statistical analysis and predictions via Monte Carlo simulation.

Study design

Experimental study.

Methods

Drug plasma and urine concentrations following single intravenous administration of flunixin 1.1 mg/kg bodyweight (BW) in 10 horses and multiple administration of q 24 hours

SUBMITTER: Kuroda T 

PROVIDER: S-EPMC9546317 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature