A "Power-to-X" Route to Acetic Acid via Palladium-Catalyzed Isomerization of Methyl Formate.

ABSTRACT: The synthesis of acetic acid by formal isomerization of methyl formate (MF) was investigated using molecular catalysts. The base-catalyzed decarbonylation of MF, yielding CO and methanol in situ, was integrated with their palladium-catalyzed recombination for the synthesis of acetic acid and methyl acetate in a one pot reaction. The complex [Pd(Cl)₂ (dppe)] [dppe=1,2-bis(diphenylphosphino)-ethane] in combination with NaI as iodide source and NaOMe as base were identified as promising molecular components to enable the overall conversion. Sequential application of the statistical methods design of experiments and simplex optimization was used in combination with thermodynamic analysis of the competing reaction pathways for experimental planning and data analysis. Starting from a

SUBMITTER: Jurling-Will P 

PROVIDER: S-EPMC9546377 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature