Farnesoid X receptor contributes to oleanolic acid-induced cholestatic liver injury in mice.

ABSTRACT: Farnesoid X receptor (FXR) is a nuclear receptor involved in the metabolism of bile acid. However, the molecular signaling of FXR in bile acid homeostasis in cholestatic drug-induced liver injury remains unclear. Oleanolic acid (OA), a natural triterpenoid, has been reported to produce evident cholestatic liver injury in mice after a long-term use. The present study aimed to investigate the role of FXR in OA-induced cholestatic liver injury in mice using C57BL/6J (WT) mice and FXR knockout (FXR^-/- ) mice. The results showed that a significant alleviation in OA-induced cholestatic liver injury was observed in FXR^-/- mice as evidenced by decreases in serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase as well as reduced hepatocyte necros

SUBMITTER: Feng H 

PROVIDER: S-EPMC9546401 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature