Neuroimaging in Glucocerebrosidase-Associated Parkinsonism: A Systematic Review.

ABSTRACT:

Background

Mutations in the GBA gene cause Gaucher's disease (GD) and constitute the most frequent genetic risk factor for idiopathic Parkinson's disease (iPD). Nonmanifesting carriers of GBA mutations/variants (GBA-NMC) constitute a potential PD preclinical population, whereas PD patients carrying some GBA mutations/variants (GBA-PD) have a higher risk of a more aggressive disease course. Different neuroimaging techniques are emerging as potential biomarkers in PD and have been used to study GBA-associated parkinsonism.

Objective

The aim is to critically review studies applying neuroimaging to GBA-associated parkinsonism.

Methods

Literature search was performed using PubMed and EMBASE databases (last search February 7, 2022). Studies reporting neuroimaging findings i

SUBMITTER: Filippi M 

PROVIDER: S-EPMC9546404 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature