Evaluation of amotosalen and UVA pathogen-reduced apheresis platelets after 7-day storage.

ABSTRACT:

Background

Amotosalen/UVA pathogen-reduced platelet components (PRPCs) with storage up to 7 days are standard of care in France, Switzerland, and Austria. PRPCs provide effective hemostasis with reduced risk of transfusion-transmitted infections and transfusion-associated graft versus host disease, reduced wastage and improved availability compared with 5-day-stored PCs. This study evaluated the potency of 7-day PRPCs by in vitro characterization and in vivo pharmacokinetic analysis of autologous PCs.

Study design and methods

The in vitro characteristics of 7-day-stored apheresis PRPCs suspended in 100% plasma or 65% platelet additive solution (PAS-3)/35% plasma, thrombin generation, and in vivo radiolabeled post-transfusion recovery and survival of 7-day-stored PRPCs suspen

SUBMITTER: Cancelas JA 

PROVIDER: S-EPMC9546462 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature