Occupation and risk of knee osteoarthritis and knee replacement: A longitudinal, multiple-cohort study.

ABSTRACT:

Objectives

To examine the effect of occupation on knee osteoarthritis (OA) and total knee replacement (TKR) in working-aged adults.

Methods

We used longitudinal data from the Chingford, Osteoarthritis Initiative (OAI) and Multicentre Osteoarthritis (MOST) studies. Participants with musculoskeletal disorders and/or a history of knee-related surgery were excluded. Participants were followed for up to 19-years (Chingford), 96-months (OAI) and 60-months (MOST) for incident outcomes including radiographic knee OA (RKOA), symptomatic RKOA and TKR. In those with baseline RKOA, progression was defined as the time from RKOA incidence to primary TKR. Occupational job categories and work-place physical activities were assigned to levels of workload. Logistic regression was used to exam

SUBMITTER: Perry TA 

PROVIDER: S-EPMC9546524 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature