Opportunistic binding of EcR to open chromatin drives tissue-specific developmental responses.

ABSTRACT: Steroid hormones perform diverse biological functions in developing and adult animals. However, the mechanistic basis for their tissue specificity remains unclear. In Drosophila, the ecdysone steroid hormone is essential for coordinating developmental timing across physically separated tissues. Ecdysone directly impacts genome function through its nuclear receptor, a heterodimer of the EcR and ultraspiracle proteins. Ligand binding to EcR triggers a transcriptional cascade, including activation of a set of primary response transcription factors. The hierarchical organization of this pathway has left the direct role of EcR in mediating ecdysone responses obscured. Here, we investigate the role of EcR in controlling tissue-specific ecdysone responses, focusing on two tissues that dive

SUBMITTER: Uyehara CM 

PROVIDER: S-EPMC9546573 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature