Expanding the genetic toolkit helps dissect a global stress response in the early-branching species Fusobacterium nucleatum.

ABSTRACT: Fusobacterium nucleatum, long known as a common oral microbe, has recently garnered attention for its ability to colonize tissues and tumors elsewhere in the human body. Clinical and epidemiological research has now firmly established F. nucleatum as an oncomicrobe associated with several major cancer types. However, with the current research focus on host associations, little is known about gene regulation in F. nucleatum itself, including global stress-response pathways that typically ensure the survival of bacteria outside their primary niche. This is due to the phylogenetic distance of Fusobacteriota to most model bacteria, their limited genetic tractability, and paucity of known gene functions. Here, we characterize a global transcriptional stress-response network

SUBMITTER: Ponath F 

PROVIDER: S-EPMC9546586 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature