Sperm-inherited H3K27me3 epialleles are transmitted transgenerationally in cis.

ABSTRACT: The transmission of chromatin states from parent cells to daughter cells preserves cell-specific transcriptional states and thus cell identity through cell division. The mechanism that underpins this process is not fully understood. The role that chromatin states serve in transmitting gene expression information across generations via sperm and oocytes is even less understood. Here, we utilized a model in which Caenorhabditis elegans sperm and oocyte alleles were inherited in different states of the repressive mark H3K27me3. This resulted in the alleles achieving different transcriptional states within the nuclei of offspring. Using this model, we showed that sperm alleles inherited without H3K27me3 were sensitive to up-regulation in offspring somatic and germline tissues, and tissu

SUBMITTER: Kaneshiro KR 

PROVIDER: S-EPMC9546627 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature