Efficacy of Corticosteroids in Infection-Related Glomerulonephritis-A Randomized Controlled Trial.

ABSTRACT:

Introduction

Infection-related glomerulonephritis (IRGN) is associated with glomerular immune complex deposition along with complement activation. Steroids may attenuate glomerular injury and thereby improve renal outcomes.

Methods

We randomly assigned patients who had biopsy-proven IRGN and serum creatinine greater than 1.5 mg/dl to receive corticosteroids plus supportive care (intervention arm), or supportive care alone (control arm). Patients were followed up for 6 months. The primary outcome was complete renal recovery at 6 months. Safety of steroid therapy was also assessed.

Results

A total of 52 patients underwent randomization. At 6 months, 17 of 26 patients (65.4%) in the intervention arm and 14 of 26 patients (53.8%) in the control arm had complete renal reco

SUBMITTER: Arivazhagan S 

PROVIDER: S-EPMC9546739 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature