Identifying the long-term survival beneficiary of chemotherapy for stage N1c sigmoid colon cancer.

ABSTRACT: Sigmoid colon cancer often has an unsatisfactory prognosis. This study explored the effect of tumor deposits (TDs) on survival, and whether their presence/absence influence individualized treatment. Data of postoperative patients with sigmoid colon cancer were extracted from the Surveillance, Epidemiology, and End Results database. Overall survival (OS) was calculated using the Kaplan-Meier method and prognostic factors were identified using Cox regression analysis and random forest (RF). The nomogram's discrimination performance was evaluated using a concordance index (C-index), integrated discrimination improvement (IDI), calibration curves, and decision-curve analysis. The N1c group showed a worse prognosis than the N0 group. For N1c patients, a combination of surgery and chemotherapy p

SUBMITTER: Liu S 

PROVIDER: S-EPMC9546836 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature