Delineating cooperative effects of Notch and biomechanical signals on patterned liver differentiation.

ABSTRACT: Controlled in vitro multicellular culture systems with defined biophysical microenvironment have been used to elucidate the role of Notch signaling in the spatiotemporal regulation of stem and progenitor cell differentiation. In addition, computational models incorporating features of Notch ligand-receptor interactions have provided important insights into Notch pathway signaling dynamics. However, the mechanistic relationship between Notch-mediated intercellular signaling and cooperative microenvironmental cues is less clear. Here, liver progenitor cell differentiation patterning was used as a model to systematically evaluate the complex interplay of cellular mechanics and Notch signaling along with identifying combinatorial mechanisms guiding progenitor fate. We present an integrated app

SUBMITTER: Jain I 

PROVIDER: S-EPMC9546876 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature